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KMID : 1044520240870020134
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Tuberculosis and Respiratory Diseases
2024 Volume.87 No. 2 p.134 ~ p.144
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Interstitial Lung Abnormality in Asian Population
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Jin Gong-Yong
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Abstract
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Interstitial lung abnormalities (ILAs) are radiologic abnormalities found incidentallyon chest computed tomography (CT) that can be show a wide range of diseases, fromsubclinical lung fibrosis to early pulmonary fibrosis including definitive usual interstitialpneumonia. To clear up confusion about ILA, the Fleischner society published aposition paper on the definition, clinical symptoms, increased mortality, radiologic progression,and management of ILAs based on several Western cohorts and articles. Recently,studies on long-term outcome, risk factors, and quantification of ILA to addressthe confusion have been published in Asia. The incidence of ILA was 7% to 10% for Westerners, while the prevalence of ILA was about 4% for Asians. ILA is closely relatedto various respiratory symptoms or increased rate of treatment-related complicationin lung cancer. There is little difference between Westerners and Asians regarding theclinical importance of ILA. Although the role of quantitative CT as a screening tool forILA requires further validation and standardized imaging protocols, using a thresholdof 5% in at least one zone demonstrated 67.6% sensitivity, 93.3% specificity, and 90.5%accuracy, and a 1.8% area threshold showed 100% sensitivity and 99% specificity inSouth Korea. Based on the position paper released by the Fleischner society, I wouldlike to report how much ILA occurs in the Asian population, what the prognosis is, andreview what management strategies should be pursued in the future.
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KEYWORD
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Interstitial Lung Abnormalities, Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis, Prognosis
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FullTexts / Linksout information
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Listed journal information
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